I’ve had a problem with Selenium’s custom profiles for a while so I settled using the fresh instance Selenium creates when it opens. I also spent quite a bit of time over the course of the past few Firefox releases figuring out how to disable the various popups and such that open when your fresh instance loads. As of Firefox 3.5.x to disable the automatic addon update checking, add these two lines to your user.js file (inside <randomstring>.default)

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